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noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related

Keywords： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

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MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 331-343 doi: 10.1007/s11684-015-0409-8

Abstract: In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3p and miR-142-5p were significantlyOverexpression of either miR-142-3p or miR-142-5p suppressed HCC cell migration, and overexpression ofboth synergistically inhibited cell migration, which indicated that miR-142-3p and miR-142-5p may cooperativelyregulate cell movement. miR-142-3p and miR-142-5p, which are mature miRNAs derived from the 3′Pathway enrichment analysis showed a strong association of the putative gene targets of miR-142-3p and

Keywords： hepatocellular carcinoma     microRNA     metastasis     cytoskeletal reorganization    

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A brief review of microRNA and its role in PRRSV infection and replication

Xuekun GUO,Wenhai FENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 114-120 doi: 10.15302/J-FASE-2014022

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV), a single-stranded RNA virus, mainly infects cells of monocyte/macrophage lineage. Recently, host microRNAs were shown to be capable of modulating PRRSV infection and replication by multiple ways such as targeting viral genomic RNA, targeting viral receptor and inducing antiviral response. MicroRNAs are small RNAs and have emerged as important regulators of virus-host cell interactions. In this review, we discuss the identified functions of host microRNAs in relation to PRRSV infection and propose that cellular microRNAs may have a substantial effect on cell or tissue tropism of PRRSV.

Keywords： porcine reproductive and respiratory syndrome virus (PRRSV)     microRNA     antiviral     viral tropism    

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Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 3,   Pages 315-322 doi: 10.1007/s11709-011-0117-7

Abstract: In this article, the third-moment reliability index, based on the three-parameter lognormal (3P-lognormal

Keywords： load and resistance factors     third-moment method     three-parameter lognormal (3P-lognormal) distribution    

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A comprehensive analysis of a 3-P (Pa) S spatial parallel manipulator

Yuzhe LIU,Liping WANG,Jun WU,Jinsong WANG

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 1,   Pages 7-19 doi: 10.1007/s11465-015-0324-3

Abstract: <p>In this paper, a novel 3-degree of freedom (3-DOF) spatial parallel kinematic machine (PKM) is analyzedp>

Keywords： parallel mechanism     concomitant motions     kinematics     workspaces     error model    

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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: Moreover, previous studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressorMoreover, RGS16 was validated as a direct target gene of miR let-7c-5p.The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking downmiR let-7c-5p had the opposite effect.Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract: <p>Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used. p>

Keywords： Treg     Forkhead box P3 (FOXP3)     Post-translational modification     Autoimmune     Cancer    

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Removal of P4, PH3 and H2S from Yellow Phosphoric Tail Gas by a Catalytic

Ning Ping,Hans-Jörg Bart,Wang Xueqian,Ma Liping,Chen Liang

Strategic Study of CAE 2005, Volume 7, Issue 6,   Pages 27-35

Abstract: <p>Yellow phosphorus tail gas is a resource to produce bulk chemicals, such as formate, oxalate, methanolproved to be effective catalysts in the catalytic oxidation process (COP) for H2S and PH33, total phosphorus＜ 5 mg/m3 was obtained by using the COP process.p>

Keywords： catalyst     catalytic oxidation     H2S     P4     PH3     fixed bed    

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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: MicroRNAs (miRNAs), small non-coding RNAs, are involved in many aspects of biological processes. Previous studies have indicated that miRNAs are important for hair follicle development and growth. In our study, we found by qRT-PCR that miR-148b was significantly upregulated in sheep wool follicle bulbs in anagen phase compared with the telogen phase of the hair follicle cycle. Overexpression of miR-148b promoted proliferation of both HHDPC and HHGMC. By using the TOPFlash system we demonstrated that miR-148b could activate Wnt/β-catenin pathway and , , and were consistently upregulated accordingly. Furthermore, transcript factor nuclear factor of activated T cells type 5 ( ) and were predicted to be the target of miR-148b and this was substantiated using a Dual-Luciferase reporter system. Subsequently was further identified as the target of miR-148b using western blotting. These results were considered to indicate that miR-148b could activate the Wnt/β-catenin signal pathway by targeting to promote the proliferation of human hair follicle cells.

Keywords： miR-148b     hair follicle     proliferation     NFAT5     Wnt10b    

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Assessment of an alternative to deep foundations in compressible clays: the structural cell foundation

MARTÍNEZ-GALVÁN, Miguel P. ROMO

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 1,   Pages 67-80 doi: 10.1007/s11709-017-0399-5

Abstract: The new type of deep foundation for buildings on saturated, compressible-low strength clayey soil deposits, branded structural cell essentially consists of a rigid concrete top slab, structurally connected to reinforced concrete peripheral walls (diaphragms) that enclose the natural soil. Accordingly, as the initial volume of the confined soft clays within the lateral stiff diaphragms will remain constant upon loading, the hollowed structural cell will be “transformed” into a very large cross-section pillar of unit weight slightly higher than that of the natural soft clayey soil. This type of foundation seems to be a highly competitive alternative to the friction pile-box foundations (widely used in Mexico City clays), due to its economic and environmental advantages. Economies result, for example, from the absence of huge excavations hence sparing the need of earth retaining structures. Further savings result from appreciably smaller concrete volumes required for building the structural cell than the friction pile-box foundation; moreover, the construction time of the former is much shorter than that of the latter. Regarding the impact to the environment, less air contamination follows from the fact that both traffic jams and soil excavation lessen appreciably. Considering these facts and others regarding scheduling, it was decided to replace 48-friction pile-box foundations specified in the master plan project by this new type of foundation. The overall behavior of these cell foundations over a five-year period is fared from close visual observations and their leveling during the first three years after their construction.

Keywords： deep foundations     bearing capacity     resistant moment     structural cell     3D numerical modeling    

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Adsorption of 1,3-propanediol from synthetic mixture using polymeric resin as adsorbents

TANTAYAKOM, P. PRASITCHOKE, C. MUANGNAPOH

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1,   Pages 52-57 doi: 10.1007/s11705-009-0087-7

Abstract: The aim of this work was to separate 1,3-PDO from a synthetic mixture using polymeric resins, Amberlite XAD-7 and XAD-16 resins. The equilibrium adsorption of 1,3-PDO onto two polymeric resins were investigated in binary and tertiary systems. Experimental results of binary component adsorption equilibrium indicated that the adsorption capacity ( ) of 1,3-PDO at 160 g/L onto XAD-7 and XAD-16 was 835.96 and 584.61 mg 1,3-PDO/g dry resin, respectively. The adsorption isotherms were closely predicted by the Langmuir-Freundlich model among the two isotherm model tested. The value of n of 1,3-PDO adsorbed on XAD-7 are much higher than those on XAD-16. This result suggested that XAD-7 resin has a higher affinity for the 1,3-PDO adsorption than XAD-16 resin. Moreover, the value of adsorption capacity of 1,3-PDO in the binary and tertiary component were compared at the same conditions. In the tertiary system, although the selectivity of 1,3-PDO from XAD-7 was approximately six times higher than XAD-16, the adsorption capacity of 1,3-PDO at 160 g/L onto XAD-16 was higher than XAD-7. Interestingly, the reusability of XAD-7 and XAD-16 resins in the three cycle times shows a slight loss of adsorption capacity. Furthermore, the investigation about desorption by an ethanol/water mixture at 50% ( / ) indicated that the desorption yield of 1,3-PDO from XAD-7 was lower than XAD-16 resin for both the binary and tertiary component. This was due to the more favorable adsorption characteristics of XAD-7 resin than XAD-16 resin.

Keywords： adsorption     1     3-propanediol     glycerol     polymeric resin     adsorption isotherm    

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MicroRNAs and hepatitis viruses

Gang LI MD , Xiaojia XIONG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 265-270 doi: 10.1007/s11684-009-0055-0

Abstract: MicroRNAs (miRNAs) are a class of small RNA molecules. They play a pivotal role in diverse domains such as infection, tumorigenesis, and immune reaction. As key regulators of most genes’ expression, they react at posttranscriptional level. It is increasingly clear that miRNAs are necessary for physiological and pathological processes. In the past few years, investigators gradually brought the concept of miRNA into studies of viral infection, including hepatitis viruses. The hepatitis B and C viruses are common causes of liver disease worldwide. It is very difficult to cure chronic hepatitis due to drug resistance during antivirus therapy. Elucidating the mechanisms of virus-host interactions in hepatitis B and C is very important in diagnosis, prognosis, and therapy. This article reviews the current knowledge of viral hepatitis (B and C type) at the level of miRNA and tries to outline areas of potential studies.

Keywords： microRNA     hepatitis B virus     hepatitis C virus    

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The role of microRNAs in adipocyte differentiation

Rong Zhang, Di Wang, Zhuying Xia, Chao Chen, Peng Cheng, Hui Xie, Xianghang Luo

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 223-230 doi: 10.1007/s11684-013-0252-8

Abstract: <p>Adipocytes differentiate from mesenchymal stem cells (MSCs) in a process known as adipogenesis.p>

Keywords： microRNA     adipocyte     differentiation     adipogenesis    

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The microRNA, miR-29c, participates in muscle development through targeting the

Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4,   Pages 311-317 doi: 10.15302/J-FASE-2015075

Abstract: Previous studies indicated that miR-29c is important for muscle development in mice and human, but its role in pigs is unknown. In this study, we detected the expression of miR-29c in Meishan longissimus lumborum (LL) muscle. The results showed that miR-29c was gradually upregulated during development of skeletal muscle in pig. Moreover, the expression of and genes, which were confirmed to be targeted by miR-29c in mice, was decreased along with muscle development. Furthermore, the expression level of miR-29c was significantly higher in adult Meishan pigs than Large White pigs, while the expression of and genes was significantly lower in Meishan pigs. These results indicated that the expression pattern of miR-29c was opposite to that of and genes in pigs. Also, the luciferase assay indicated that miR-29s can target the gene in pigs. In addition, we identified a T to C mutation in the primary transcript of miR-29c, which was associated with the postmortem muscle pH in pigs. Based on these results, we concluded that miR-29c is also important in skeletal muscle development of pigs.

Keywords： pig     miR-29c     skeletal muscle     expression     SNP    

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Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 404-418 doi: 10.1007/s11684-014-0379-2

Abstract: <p>microRNAs (miRNAs) are a class of conserved, short, non-coding RNAs that have important and potentp>

Keywords： microRNA     cardiovascular disease     biomarkers     therapeutic target    

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Title Author Date Type Operation

noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Journal Article

MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Journal Article

A brief review of microRNA and its role in PRRSV infection and replication

Xuekun GUO,Wenhai FENG

Journal Article

Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

Journal Article

A comprehensive analysis of a 3-P (Pa) S spatial parallel manipulator

Yuzhe LIU,Liping WANG,Jun WU,Jinsong WANG

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Removal of P4, PH3 and H2S from Yellow Phosphoric Tail Gas by a Catalytic

Ning Ping,Hans-Jörg Bart,Wang Xueqian,Ma Liping,Chen Liang

Journal Article

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

Assessment of an alternative to deep foundations in compressible clays: the structural cell foundation

MARTÍNEZ-GALVÁN, Miguel P. ROMO

Journal Article

Adsorption of 1,3-propanediol from synthetic mixture using polymeric resin as adsorbents

TANTAYAKOM, P. PRASITCHOKE, C. MUANGNAPOH

Journal Article

MicroRNAs and hepatitis viruses

Gang LI MD , Xiaojia XIONG MM ,

Journal Article

The role of microRNAs in adipocyte differentiation

Rong Zhang, Di Wang, Zhuying Xia, Chao Chen, Peng Cheng, Hui Xie, Xianghang Luo

Journal Article

The microRNA, miR-29c, participates in muscle development through targeting the

Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI

Journal Article

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Journal Article